Elucidation of a Role for Stromal Steroid Hormone Receptors in Mammary Gland Growth and Development Using Tissue Recombinants

@article{Cunha1997ElucidationOA,
  title={Elucidation of a Role for Stromal Steroid Hormone Receptors in Mammary Gland Growth and Development Using Tissue Recombinants},
  author={Gerald R. Cunha and Peter Young and Yun Kit Hom and Paul S. Cooke and J. Andrew Taylor and Dennis B. Lubahn},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={1997},
  volume={2},
  pages={393-402}
}
The use of tissue recombinants in conjunction with steroid receptor deficient mice is described as a tool to dissect the complex paracrine pathways of sex-hormone-regulated epithelial growth and ductal morphogenesis in the mammary gland and other hormone target organs. The basic methodology involves the construction of the four possible tissue recombinants composed of epithelium (E)6 and stroma (S) from wild-type (wt) and knock-out (KO) mice: wt-S + wt-S, wt-S + KO-E, KO-S + KO-E, and KO-S + wt… CONTINUE READING
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