Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR.

@article{Kim2007ElucidationOA,
  title={Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR.},
  author={Henry S. Kim and Yuki Kuwano and Ming Zhan and Rudolf Pullmann and Krystyna Mazan-Mamczarz and Huai Zhong Li and Nancy L. Kedersha and Paul Anderson and Matthew Charles James Wilce and Myriam Gorospe and Jacqueline A Wilce},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 19},
  pages={6806-17}
}
The RNA-binding protein TIAR (related to TIA-1 [T-cell-restricted intracellular antigen 1]) was shown to associate with subsets of mRNAs bearing U-rich sequences in their 3' untranslated regions. TIAR can function as a translational repressor, particularly in response to cytotoxic agents. Using unstressed colon cancer cells, collections of mRNAs associated with TIAR were isolated by immunoprecipitation (IP) of (TIAR-RNA) ribonucleoprotein (RNP) complexes, identified by microarray analysis, and… CONTINUE READING