Elucidation of Toxicity Pathways in Lung Epithelial Cells Induced by Silicon Dioxide Nanoparticles

@inproceedings{OkoturoEvans2013ElucidationOT,
  title={Elucidation of Toxicity Pathways in Lung Epithelial Cells Induced by Silicon Dioxide Nanoparticles},
  author={Odu Okoturo-Evans and Agnieszka D Dybowska and Eugenia Valsami-Jones and John Cupitt and Magdalena Gierula and Alan R Boobis and Robert J. Edwards},
  booktitle={PloS one},
  year={2013}
}
A study into the effects of amorphous nano-SiO2 particles on A549 lung epithelial cells was undertaken using proteomics to understand the interactions that occur and the biological consequences of exposure of lung to nanoparticles. Suitable conditions for treatment, where A549 cells remained viable for the exposure period, were established by following changes in cell morphology, flow cytometry, and MTT reduction. Label-free proteomics was used to estimate the relative level of proteins from… CONTINUE READING
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  • F Sandford
  • Nature Nanotechnology
  • 2013

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