Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses.

@article{Itoh2003ElucidationOS,
  title={Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses.},
  author={Susumu Itoh and Midory Thorikay and Marcin Kowanetz and Aristidis Moustakas and Fumiko Itoh and C M Heldin and Peter Ten Dijke},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 6},
  pages={3751-61}
}
Transforming growth factor-beta (TGF-beta) elicits cellular effects by activating specific Smad proteins that control the transcription of target genes. Whereas there is growing evidence that there are TGF-beta type I receptor-initiated intracellular pathways that are distinct from the pivotal Smad pathway, their physiological importance in TGF-beta signaling is not well understood. Therefore, we generated TGF-beta type I receptors (also termed ALK5s) with mutations in the L45 loop of the… CONTINUE READING
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