Elucidation, quantitative refinement, and in vivo utilization of the HOXA13 DNA binding site.

@article{Knosp2007ElucidationQR,
  title={Elucidation, quantitative refinement, and in vivo utilization of the HOXA13 DNA binding site.},
  author={Wendy M Knosp and Chie Saneyoshi and Siming Shou and Hans Peter B{\"a}chinger and Hannes Stadler},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 9},
  pages={6843-53}
}
Mutations in Hoxa13 cause malformations of the appendicular skeleton and genitourinary tract, including digit loss, syndactyly, and hypospadias. To determine the molecular basis for these defects, the DNA sequences bound by HOXA13 were empirically determined, revealing a novel high affinity binding site. Correlating the utilization of this high affinity binding site with genes exhibiting perturbed expression in Hoxa13 mutant limbs, we identified that HOXA13 suppresses the expression of the BMP… CONTINUE READING

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HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death.

Developmental dynamics : an official publication of the American Association of Anatomists • 2013
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Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.

Developmental dynamics : an official publication of the American Association of Anatomists • 2010
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References

Publications referenced by this paper.

45324545 by gest on Sptem er 1, 2017 hp://w w w .jb.org/ D

I. Pellerin, C. Schnabel, K. M. Catron, C. Abate
Mol Cell Biol • 1994

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