Elucidating the role of the mucus-associated microbiota and mucin glycosylation in inflammatory bowel disease

@inproceedings{Thursby2016ElucidatingTR,
  title={Elucidating the role of the mucus-associated microbiota and mucin glycosylation in inflammatory bowel disease},
  author={Elizabeth Thursby},
  year={2016}
}
The human gastrointestinal (GI) tract is host to a dynamic community of 10-10 bacteria, which mainly reside in the colonic lumen and outer mucus layer covering the GI tract. Mucins are decorated in a diverse array of O-glycans, providing nutrients and attachment sites for microbes. Dysbiosis of the microbiota, and alterations in mucin glycosylation have been associated with Inflammatory Bowel Disease (IBD). However, the causal relationship between these two factors remains unclear. Here, we… CONTINUE READING

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