Elucidating the role of molecular signaling pathways in the tumorigenesis of basal cell carcinoma.

  • J. H. Tang
  • Published 2011 in Seminars in cutaneous medicine and surgery


The Hedgehog signaling pathway has been identified as fundamentally important to normal embryonic development in living organisms ranging from fruit flies to mammals. Postdevelopmentally, it remains active in hair and skin cells. Abnormal activation of components of the Hedgehog pathway--specifically, resulting from mutations in the Patched 1 gene--is… (More)
DOI: 10.1016/j.sder.2011.11.001


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