Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112

@inproceedings{Dong2015ElucidatingTI,
  title={Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112},
  author={Dong Dong and Xiao Wang and Huailing Wang and Xingwang Zhang and Yifei Wang and Baojian Wu},
  booktitle={International journal of nanomedicine},
  year={2015}
}
INTRODUCTION SNX-2112 is a promising anticancer agent but has poor solubility in both water and oil. In the study reported here, we aimed to develop a nanocrystal formulation for SNX-2112 and to determine the pharmacokinetic behaviors of the prepared nanocrystals. METHODS Nanocrystals of SNX-2112 were prepared using the wet-media milling technique and characterized by particle size, differential scanning calorimetry, drug release, etc. Physiologically based pharmacokinetic (PBPK) modeling was… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Similar Papers

Loading similar papers…