Elucidating the genetic basis for Escherichia coli defense against silver toxicity using mutant arrays.

Abstract

Bacterial adaptation and defense mechanisms against silver are poorly understood at the genetic level. A library of Escherichia coli gene-deletion mutants was used to show that clones lacking sodB (coding for oxidative stress protection), lon (protein damage repair), or cusR (metal efflux pump) are quite sensitive to silver (with 7.3 ± 9.1%, 5.3 ± 1.8%, and… (More)
DOI: 10.1002/etc.2514

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