Elucidating the encapsulation of short interfering RNA in PEGylated cationic liposomes.

Abstract

Short interfering RNA (siRNA) holds great potential for the treatment of hard-to-cure diseases. One of the major challenges to translate siRNA into drugs is its efficient delivery to its site-of-action, namely the cytoplasm of the target cells. Cationic liposomes have been shown to do the trick, but their short circulation lifetime and potential aggregation… (More)
DOI: 10.1021/la803973p

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Cite this paper

@article{Buyens2009ElucidatingTE, title={Elucidating the encapsulation of short interfering RNA in PEGylated cationic liposomes.}, author={Kevin Buyens and Joseph Demeester and Stefaan S De Smedt and Niek N Sanders}, journal={Langmuir : the ACS journal of surfaces and colloids}, year={2009}, volume={25 9}, pages={4886-91} }