Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.

@article{Lam2006ElucidatingTE,
  title={Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.},
  author={Justine L. Lam and Sarah B Shugarts and Hideaki Okochi and Leslie Z Benet},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={319 2},
  pages={864-70}
}
Because rifampin (RIF) induces hepatic enzymes and inhibits uptake transporters, dosing a drug that is a dual substrate of enzymes and uptake transporters on the final day of an inducing regimen should exhibit less inductive effect than dosing on the following day in the absence of RIF, since RIF decreases drug uptake into liver. In vitro and in vivo rat studies were conducted using digoxin as a model substrate. Digoxin was administered to an uninduced control group to obtain baseline values… CONTINUE READING

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