Elucidating the Sources of β-Catenin Dynamics in Human Neural Progenitor Cells

  title={Elucidating the Sources of β-Catenin Dynamics in Human Neural Progenitor Cells},
  author={Orianne Mazemondet and Mathias John and Stefan Leye and Arndt Rolfs and Adelinde M. Uhrmacher},
  booktitle={PloS one},
Human neural progenitor cells (hNPCs) form a new prospect for replacement therapies in the context of neurodegenerative diseases. The Wnt/β-catenin signaling pathway is known to be involved in the differentiation process of hNPCs. RVM cells form a common cell model of hNPCs for in vitro investigation. Previous observations in RVM cells raise the question of whether observed kinetics of the Wnt/β-catenin pathway in later differentiation phases are subject to self-induced signaling. However, a… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 12 extracted citations


Publications referenced by this paper.
Showing 1-10 of 61 references

Wnt signalling and the control of cellular metabolism.

The Biochemical journal • 2010
View 4 Excerpts
Highly Influenced

Differentiation of human neural progenitor cells regulated by Wnt-3a.

Biochemical and biophysical research communications • 2010
View 1 Excerpt

Mathematical modelling of Wnt/β-catenin signalling.

Biochemical Society transactions • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…