Elucidating the Sources of β-Catenin Dynamics in Human Neural Progenitor Cells

@inproceedings{Mazemondet2012ElucidatingTS,
  title={Elucidating the Sources of β-Catenin Dynamics in Human Neural Progenitor Cells},
  author={Orianne Mazemondet and Mathias John and Stefan Leye and Arndt Rolfs and Adelinde M. Uhrmacher},
  booktitle={PloS one},
  year={2012}
}
Human neural progenitor cells (hNPCs) form a new prospect for replacement therapies in the context of neurodegenerative diseases. The Wnt/β-catenin signaling pathway is known to be involved in the differentiation process of hNPCs. RVM cells form a common cell model of hNPCs for in vitro investigation. Previous observations in RVM cells raise the question of whether observed kinetics of the Wnt/β-catenin pathway in later differentiation phases are subject to self-induced signaling. However, a… CONTINUE READING
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