Elucidating the Role of Dose in the Biopharmaceutics Classification of Drugs: The Concepts of Critical Dose, Effective In Vivo Solubility, and Dose-Dependent BCS

@article{Charkoftaki2012ElucidatingTR,
  title={Elucidating the Role of Dose in the Biopharmaceutics Classification of Drugs: The Concepts of Critical Dose, Effective In Vivo Solubility, and Dose-Dependent BCS},
  author={Georgia Charkoftaki and Aristides Dokoumetzidis and Georgia N. Valsami and Panos Macheras},
  journal={Pharmaceutical Research},
  year={2012},
  volume={29},
  pages={3188-3198}
}
To develop a dose dependent version of BCS and identify a critical dose after which the amount absorbed is independent from the dose. We utilized a mathematical model of drug absorption in order to produce simulations of the fraction of dose absorbed (F) and the amount absorbed as function of the dose for the various classes of BCS and the marginal cases in between classes. Simulations based on the mathematical model of F versus dose produced patterns of a constant F throughout a wide range of… CONTINUE READING

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