Elucidating the Mechanism of Absorption of Fast-Acting Insulin Aspart: The Role of Niacinamide

@article{Kildegaard2019ElucidatingTM,
  title={Elucidating the Mechanism of Absorption of Fast-Acting Insulin Aspart: The Role of Niacinamide},
  author={J. Kildegaard and S. Buckley and R. H. Nielsen and G. Povlsen and T. Seested and U. Ribel and H. Olsen and S. Ludvigsen and C. Jeppesen and H. H. Refsgaard and K. M. Bendtsen and N. R. Kristensen and Susanne Hostrup and J. Sturis},
  journal={Pharmaceutical Research},
  year={2019},
  volume={36}
}
PurposeFast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart containing two additional excipients: niacinamide, to increase early absorption, and L-arginine, to optimize stability. The aim of this study was to evaluate the impact of niacinamide on insulin aspart absorption and to investigate the mechanism of action underlying the accelerated absorption.MethodsThe impact of niacinamide was assessed in pharmacokinetic analyses in pigs and humans, small angle X-ray… Expand
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