Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling.

@article{Azim2012ElucidatingPA,
  title={Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling.},
  author={Hatem A. Azim and Stefan Michiels and Philippe L B{\'e}dard and Sandeep K. Singhal and Carmen Criscitiello and Michail G Ignatiadis and Benjamin Haibe-Kains and Martine J. Piccart and Christos Sotiriou and Sherene Loi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 5},
  pages={1341-51}
}
PURPOSE Breast cancer in young women is associated with poor prognosis. We aimed to define the role of gene expression signatures in predicting prognosis in young women and to understand biological differences according to age. EXPERIMENTAL DESIGN Patients were assigned to molecular subtypes [estrogen receptor (ER)(+)/HER2(-); HER2(+), ER(-)/HER2(-))] using a three-gene classifier. We evaluated whether previously published proliferation, stroma, and immune-related gene signatures added… CONTINUE READING