Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia

@article{Holyoake2002ElucidatingCM,
  title={Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia},
  author={Tessa Holyoake and X Jiang and Matthew Thomson Drummond and A Eaves and C J Eaves},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={549-558}
}
Chronic myeloid leukemia (CML) has been studied intensively for many years; yet its treatment remains problematic and its biology remains elusive. In chronic phase, the leukemic clone appears to be maintained by a small number of BCR-ABL-positive hematopoietic stem cells that differentiate normally and amplify slowly. In contrast, as these cells enter the intermediate stages of lineage restriction, their progeny are selectively expanded and generate an enlarged pool of neoplastic progenitors… CONTINUE READING
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