Elucidating and reprogramming Escherichia coli metabolisms for obligate anaerobic n-butanol and isobutanol production

@article{Trinh2012ElucidatingAR,
  title={Elucidating and reprogramming Escherichia coli metabolisms for obligate anaerobic n-butanol and isobutanol production},
  author={Cong T. Trinh},
  journal={Applied Microbiology and Biotechnology},
  year={2012},
  volume={95},
  pages={1083-1094}
}
  • Cong T. Trinh
  • Published 2012
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
Elementary mode (EM) analysis based on the constraint-based metabolic network modeling was applied to elucidate and compare complex fermentative metabolisms of Escherichia coli for obligate anaerobic production of n-butanol and isobutanol. The result shows that the n-butanol fermentative metabolism was NADH-deficient, while the isobutanol fermentative metabolism was NADH redundant. E. coli could grow and produce n-butanol anaerobically as the sole fermentative product but not achieve the… Expand
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