Elucidating Isoniazid Resistance in Mycobacterium Tuberculosis Using Molecular Docking Approach


Isoniazid, an important drug in the anti-tuberculosis therapy, the enzyme catalase-peroxidase (KatG) plays a key role in activating isoniazid (INH). Mutation in katG gene is a major mechanism of INH resistance in M. tuberculosis. Several derivatives of INH show activity against TB and multi-drug resistant TB. With the aim of finding new compounds, in this… (More)


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