Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson’s disease: a dose-finding study

@inproceedings{Svenningsson2015EltoprazineCL,
  title={Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson’s disease: a dose-finding study},
  author={Per Svenningsson and Carl Rosenblad and Karolina af Edholm Arvidsson and Klas Wictorin and Charlotte Keywood and Bavani Shankar and David Allan Lowe and Anders Bjoerklund and H{\aa}kan Widner},
  booktitle={Brain : a journal of neurology},
  year={2015}
}
In advanced stages of Parkinson's disease, serotonergic terminals take up L-DOPA and convert it to dopamine. Abnormally released dopamine may participate in the development of L-DOPA-induced dyskinesias. Simultaneous activation of 5-HT1A and 5-HT1B receptors effectively blocks L-DOPA-induced dyskinesias in animal models of dopamine depletion, justifying a clinical study with eltoprazine, a 5-HT1A/B receptor agonist, against L-DOPA-induced dyskinesias in patients with Parkinson's disease. A… CONTINUE READING

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