Elsamicin A can convert the Z-form of poly[d(G-C)] and poly[(G-m5C)] back to B-form DNA.

@article{JimnezGarca1992ElsamicinAC,
  title={Elsamicin A can convert the Z-form of poly[d(G-C)] and poly[(G-m5C)] back to B-form DNA.},
  author={Eduardo Jim{\'e}nez-Garc{\'i}a and Jos{\'e} Portugal},
  journal={Biochemistry},
  year={1992},
  volume={31 46},
  pages={
          11641-6
        }
}
The interaction of poly[(G-C)] and poly[d(G-m5C)] with the antitumor antibiotic elsamicin A, which binds to alternating guanine + cytosine tracts in DNA, has been studied under the B and Z conformations. Both the rate and the extent of the B-to-Z transition are diminished by the antibiotic, as inferred by spectroscopic methods under ionic conditions that otherwise favor the left-handed conformation of the polynucleotides. Moreover, elsamicin converts the Z-form DNA back to the B-form. The… 
11 Citations
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Thermodynamic characterization of the multivalent binding of chartreusin to DNA.
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A detailed thermodynamic profile is obtained for the interaction of this multivalent drug, which makes possible a dissection of DeltaG(obs) into the component free energy terms.
Molecular dynamics study of the binding of elsamicin A to DNA.
TLDR
Molecular mechanics and dynamics were used to examine the conformational flexibility of elsamicin A, an antitumour antibiotic, in aqueous solution and obtained the first three-dimensional model of the el samicin-A-DNA complex.
Modulation of DNA structure formation using small molecules.
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The present results indicate that guanine-specific recognition and selective cleavage of DNA by the antitumor antibiotic elsamicin A equipped with an amino sugar and compare these results with cleavage by chartarin and chartreusin antibiotics and found that an acetylation of the amino group on the elsamsicin A sugar portion plays an interesting switch function for the activity of elsamyin A.
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