Elovl6: a new player in fatty acid metabolism and insulin sensitivity

  title={Elovl6: a new player in fatty acid metabolism and insulin sensitivity},
  author={Takashi Matsuzaka and Hitoshi Shimano},
  journal={Journal of Molecular Medicine},
Obesity is a major health problem in industrialized societies often associated with diabetes, insulin resistance, and hepatic steatosis. This review addresses the hypothesis that elongation of long-chain fatty acids family member 6 (Elovl6) has an important role in energy metabolism and insulin sensitivity. Elovl6 is a microsomal enzyme involved in the elongation of saturated and monounsaturated fatty acids with 12, 14, and 16 carbons. Mice with targeted disruption in the gene for Elovl6… CONTINUE READING
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