Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products.

@article{Schoenfeld2000ElonginBC,
  title={Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products.},
  author={Alan R. Schoenfeld and Eliot J. Davidowitz and Robert D Burk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 15},
  pages={8507-12}
}
Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the familial cancer syndrome, VHL disease, characterized by a predisposition to renal cell carcinoma and other tumor types. Loss of VHL gene function also is found in a majority of sporadic renal carcinomas. A preponderance of the tumor-disposing inherited missense mutations detected in VHL disease are within the elongin-binding domain of VHL. This region mediates the formation of a multiprotein VHL complex containing… CONTINUE READING
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