Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.

@article{Winkler2002ElongatorIA,
  title={Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.},
  author={G. Sebastiaan Winkler and Arnold Kristjuhan and Hediye Erdjument-Bromage and Paul Tempst and Jesper Qualmann Svejstrup},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 6},
  pages={3517-22}
}
The elongating, hyperphosphorylated form of RNA polymerase II is associated with the Elongator complex, which has the histone acetyltransferase (HAT) Elp3 as a subunit. Here we show that, in contrast to the isolated Elp3 subunit, the activity of intact Elongator complex is directed specifically toward the amino-terminal tails of histone H3 and H4, and that Elongator can acetylate both core histones and nucleosomal substrates. The predominant acetylation sites are lysine-14 of histone H3 and… CONTINUE READING
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