Elongation of centriolar microtubule triplets contributes to the formation of the mitotic spindle in gamma-tubulin-depleted cells.

@article{RaynaudMessina2004ElongationOC,
  title={Elongation of centriolar microtubule triplets contributes to the formation of the mitotic spindle in gamma-tubulin-depleted cells.},
  author={Brigitte Raynaud-Messina and Laurent Mazzolini and Andr{\'e} Moisand and A Cirinesi and Michel Wright},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 23},
  pages={5497-507}
}
The assembly of the mitotic spindle after depletion of the major gamma-tubulin isotype by RNA-mediated interference was assessed in the Drosophila S2 cell line. Depletion of gamma-tubulin had no significant effect on the cytoskeletal microtubules during interphase. However, it promoted an increase in the mitotic index, resulting mainly in monopolar and, to a lesser extent, asymmetrical bipolar prometaphases lacking astral microtubules. This mitotic accumulation coincided with the activation of… CONTINUE READING

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