Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action.

@article{Parmeggiani2006ElongationFT,
  title={Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action.},
  author={Andrea Parmeggiani and Poul Nissen},
  journal={FEBS letters},
  year={2006},
  volume={580 19},
  pages={
          4576-81
        }
}
Elongation factor Tu (EF-Tu), the carrier of aa-tRNA to the mRNA-programmed ribosome, is the target of four families of antibiotics of unrelated structure, of which the action is supported by two basic mechanisms. Kirromycin and enacyloxin block EF-Tu.GDP on the ribosome; pulvomycin and GE2270 A inhibit the interaction of EF-Tu.GTP with aa-tRNA. The crystallographic analysis has unveiled the structural background of their actions, explaining how antibiotics of unrelated structures and binding… CONTINUE READING
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