Elongation factor-2 kinase: its role in protein synthesis and autophagy.

  title={Elongation factor-2 kinase: its role in protein synthesis and autophagy.},
  author={William N. Hait and Hao Wu and Shenkan Jin and Jin-ming Yang},
  volume={2 4},
Elongation factor-2 kinase (eEF-2 kinase; Ca(2+)/calmodulin-dependent kinase III) controls the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in many malignancies, yet its precise function in carcinogenesis remains unknown. Autophagy, a well-defined survival pathway in yeast, may also play an important role in oncogenesis. Furthermore, the autophagic response to nutrient deprivation is regulated by the mammalian target of rapamycin (mTOR). eEF-2 kinase lies… CONTINUE READING


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