Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

@article{Park2008ElongationF2,
  title={Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD},
  author={Sungjin Park and Joo Min Park and Sangmok Kim and Jin-ah Kim and Jason D Shepherd and Constance Leonie Smith-Hicks and Shoaib Chowdhury and Walter Arnold Kaufmann and Dietmar Kuhl and Alexey G. Ryazanov and Richard L. Huganir and David J Linden and Paul F Worley},
  journal={Neuron},
  year={2008},
  volume={59},
  pages={70-83}
}
Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires eEF2K, a Ca(2+)/calmodulin-dependent kinase that binds mGluR and dissociates upon mGluR activation, whereupon it phosphorylates eEF2. Phospho-eEF2 acts to slow the elongation step… CONTINUE READING
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FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2007
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

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