Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

  title={Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex},
  author={Catherine M. Sutherland and Simon Hawley and Rhonda R. McCartney and Anna M Leech and Michael J R Stark and Martin Schmidt and D.Grahame Hardie},
  journal={Current Biology},
BACKGROUND The yeast SNF1 protein kinase and the mammalian AMP-activated protein kinase are highly conserved heterotrimeric complexes that are "metabolic master switches" involved in the switch from fermentative/anaerobic to oxidative metabolism. They are activated by cellular stresses that deplete cellular ATP, and SNF1 is essential in the response to glucose starvation. In both cases, activation requires phosphorylation at a conserved threonine residue within the activation loop of the kinase… CONTINUE READING
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