ElliPro: a new structure-based tool for the prediction of antibody epitopes

  title={ElliPro: a new structure-based tool for the prediction of antibody epitopes},
  author={Julia V. Ponomarenko and Huynh-Hoa Bui and Wei Li and Nicholas Fusseder and Philip E. Bourne and Alessandro Sette and Bjoern Peters},
  journal={BMC Bioinformatics},
  pages={514 - 514}
Reliable prediction of antibody, or B-cell, epitopes remains challenging yet highly desirable for the design of vaccines and immunodiagnostics. A correlation between antigenicity, solvent accessibility, and flexibility in proteins was demonstrated. Subsequently, Thornton and colleagues proposed a method for identifying continuous epitopes in the protein regions protruding from the protein's globular surface. The aim of this work was to implement that method as a web-tool and evaluate its… CONTINUE READING
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Prediction of residues in discontinuous B-cell epitopes using protein 3D structures

  • P Haste Andersen, M Nielsen, O Lund
  • Protein Sci
  • 2006
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