Ellagic acid protects rat embryos in culture from the embryotoxic effects of N-methyl-N-nitrosourea.
@article{Frank1992EllagicAP, title={Ellagic acid protects rat embryos in culture from the embryotoxic effects of N-methyl-N-nitrosourea.}, author={A. Frank and J. Collier and C. Forsyth and Y. Heur and G. Stoner}, journal={Teratology}, year={1992}, volume={46 2}, pages={ 109-15 } }
Ellagic acid is a naturally occurring plant phenol that has demonstrated anticarcinogenic and antimutagenic activity in several test systems. Given the common proposed etiopathogenic processes of mutagenesis, carcinogenesis, and teratogenesis induced by genotoxic chemicals, the present study was initiated to determine whether ellagic acid would protect rat embryos in culture from the teratogenic effects of N-methyl-N-nitrosourea (MNU). Ellagic acid alone (as used in these experiments; 50 microM… CONTINUE READING
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References
SHOWING 1-10 OF 38 REFERENCES
Ellagic acid metabolism and binding to DNA in organ explant cultures of the rat.
- Biology, Medicine
- Cancer letters
- 1987
- 30
Protective effects of ellagic acid and other plant phenols on benzo[a]pyrene-induced neoplasia in mice.
- Biology, Medicine
- Carcinogenesis
- 1983
- 185
Effect of ellagic acid on hepatic and pulmonary xenobiotic metabolism in mice: studies on the mechanism of its anticarcinogenic action.
- Biology, Medicine
- Carcinogenesis
- 1985
- 86
Reevaluation of the effect of ellagic acid on N-methyl-N-nitrosourea DNA alkylation and mutagenicity.
- Chemistry, Medicine
- Chemical research in toxicology
- 1990
- 3
Inhibition of N-nitrosobenzylmethylamine metabolism and DNA binding in cultured rat esophagus by ellagic acid.
- Biology, Medicine
- Carcinogenesis
- 1988
- 59
Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1986
- 94
- PDF
Inhibitory Effect of Ellagic Acid on N‐2‐Fluorenylacetamide‐induced Liver Carcinogenesis in Male ACI/N Rats
- Biology, Medicine
- Japanese journal of cancer research : Gann
- 1988
- 61
Ellagic acid binding to DNA as a possible mechanism for its antimutagenic and anticarcinogenic action.
- Chemistry, Medicine
- Cancer letters
- 1986
- 93
Protection against 3-methylcholanthrene-induced skin tumorigenesis in Balb/C mice by ellagic acid.
- Chemistry, Medicine
- Biochemical and biophysical research communications
- 1984
- 97
Inhibition of 3-methylcholanthrene-induced skin tumorigenicity in BALB/c mice by chronic oral feeding of trace amounts of ellagic acid in drinking water.
- Biology, Medicine
- Cancer research
- 1986
- 93
- PDF