Ellagic Acid Controls Cell Proliferation and Induces Apoptosis in Breast Cancer Cells via Inhibition of Cyclin-Dependent Kinase 6

  title={Ellagic Acid Controls Cell Proliferation and Induces Apoptosis in Breast Cancer Cells via Inhibition of Cyclin-Dependent Kinase 6},
  author={Mohd. Yousuf and Anas Shamsi and Parvez Khan and Mohd. Shahbaaz and Mohamed F Alajmi and Afzal Hussain and Gulam Hassan and Asimul Islam and Qazi Mohd Rizwanul Haque and Md. Imtaiyaz Hassan},
  journal={International Journal of Molecular Sciences},
Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus, it is considered as an attractive drug target in anticancer therapeutics. This study presents an evaluation of dietary phytochemicals, capsaicin, tocopherol, rosmarinic acid, ursolic acid, ellagic acid (EA), limonene, caffeic acid, and ferulic acid for their potential to inhibit the activity of CDK6. Molecular docking and fluorescence binding studies revealed appreciable binding affinities of these… 

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