Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death

  title={Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death},
  author={J. M. Molina-Guijarro and Carolina Garc{\'i}a and A. Macias and L. Garc{\'i}a-Fern{\'a}ndez and Cristina Moreno and F. Reyes and J. F. Mart{\'i}nez-Leal and R. Fernández and Valent{\'i}n Mart{\'i}nez and C. Valenzuela and M. Lillo and C. Galmarini},
  journal={PLoS ONE},
Plasma membrane integrity is essential for cell life. Any major break on it immediately induces the death of the affected cell. Different molecules were described as disrupting this cell structure and thus showing antitumor activity. We have previously defined that elisidepsin (Irvalec®, PM02734) inserts and self-organizes in the plasma membrane of tumor cells, inducing a rapid loss of membrane integrity, cell permeabilization and necrotic death. Here we show that, in sensitive HCT-116… Expand
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