Elimination of sodium hyaluronate-induced decrease in outflow facility with hyaluronidase.

@article{Hein1986EliminationOS,
  title={Elimination of sodium hyaluronate-induced decrease in outflow facility with hyaluronidase.},
  author={Scott E. Hein and R H Keates and Paul A. Weber},
  journal={Ophthalmic surgery},
  year={1986},
  volume={17 11},
  pages={731-4}
}
The use of intraocular sodium hyaluronate is complicated by a postoperative rise in intraocular pressure (IOP). The rise in IOP is thought to stem from a "clogging" at the trabecular meshwork by the large molecules of hyaluronate. This study uses serial tonographic measurements in an animal model to document this change in outflow facility. Furthermore, we investigate the ability of the enzyme hyaluronidase to cleave the hyaluronate into smaller molecular weight fragments, in vivo, and thereby… CONTINUE READING