Elimination of radiation-induced gamma-H2AX foci in mammalian nucleus can occur by histone exchange.

@article{Svetlova2007EliminationOR,
  title={Elimination of radiation-induced gamma-H2AX foci in mammalian nucleus can occur by histone exchange.},
  author={Maria Pavlovna Svetlova and Liudmila V. Solovjeva and Kayoko Nishi and I. S. Nazarov and Joseph S. Siino and Nikolai Tomilin},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={358 2},
  pages={650-4}
}
Double-strand breaks in mammalian DNA lead to rapid phosphorylation of C-terminal serines in histone H2AX (gamma-H2AX) and formation of large nuclear gamma-H2AX foci. After DNA repair these foci disappear, but molecular mechanism of elimination of gamma-H2AX foci remains unclear. H2AX protein can be phosphorylated and dephosphorylated in vitro in the absence of chromatin. Here, we compared global exchange of GFP-H2AX with kinetics of formation and elimination of radiation-induced gamma-H2AX… CONTINUE READING

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