Elimination of prions by branched polyamines and implications for therapeutics.

  title={Elimination of prions by branched polyamines and implications for therapeutics.},
  author={Surachai Supattapone and Hoang X. Nguyen and Fred E. Cohen and Stanley B Prusiner and Michael R. Van Scott},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 25},
We report that branched polyamines, including polyamidoamide dendimers, polypropyleneimine, and polyethyleneimine, are able to purge PrP(Sc), the protease-resistant isoform of the prion protein, from scrapie-infected neuroblastoma (ScN2a) cells in culture. The removal of PrP(Sc) by these compounds depends on both the concentration of branched polymer and the duration of exposure. Chronic exposure of ScN2a cells to low noncytotoxic concentrations of branched polyamines for 1 wk reduced PrP(Sc… CONTINUE READING


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