Elimination of foreign DNA during somatic differentiation in Tetrahymena thermophila shows position effect and is dosage dependent.

@article{Liu2005EliminationOF,
  title={Elimination of foreign DNA during somatic differentiation in Tetrahymena thermophila shows position effect and is dosage dependent.},
  author={Yifan Liu and Xiaoyuan Song and M. A. Gorovsky and K. M. Karrer},
  journal={Eukaryotic cell},
  year={2005},
  volume={4 2},
  pages={421-31}
}
In the ciliate Tetrahymena thermophila, approximately 15% of the germ line micronuclear DNA sequences are eliminated during formation of the somatic macronucleus. The vast majority of the internal eliminated sequences (IESs) are repeated in the micronuclear genome, and several of them resemble transposable elements. Thus, it has been suggested that DNA elimination evolved as a means for removing invading DNAs. In the present study, bacterial neo genes introduced into the germ line micronuclei… CONTINUE READING