Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport.

@article{Babiker1997EliminationOC,
  title={Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport.},
  author={Amir H. M. Babiker and Olov Andersson and Elsebet Lund and R. L. Mei Xiu and Safaa I. El Deeb and Ayelet Reshef and Eran Leitersdorf and Ulf Diczfalusy and Ingemar Bj{\"o}rkhem},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 42},
  pages={
          26253-61
        }
}
Cultured macrophages and endothelial cells have been reported to secrete 27-oxygenated metabolites of cholesterol. This mechanism was compared with the classical high density lipoprotein (HDL)-dependent reverse cholesterol transport. Under standard conditions, macrophage preparations had considerably higher capacity to secrete 27-hydroxycholesterol and 3beta-hydroxy-5-cholestenoic acid than had endothelial cells and fibroblasts. Western blotting showed that lung macrophages contained the most… CONTINUE READING

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