Elimination of antipyrine from saliva as a measure of metabolism in man

@article{Welch1975EliminationOA,
  title={Elimination of antipyrine from saliva as a measure of metabolism in man},
  author={R. Welch and R. Deangelis and M. Wingfield and T. Farmer},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1975},
  volume={18}
}
The salivary half‐life of antipyrine was used as a convenient procedure for estimating the relative rates of drug metabolism in man. The concentration ratio of antipyrine in plasma and saliva was one over a 24‐hr period following the oral or parenteral administration of the drug to man and rat. Phenobarbital, a known stimulator of drug metabolism in animals and man, increased markedly the elimination of antipyrine from saliva of rats, while SKF‐525A, a potent inhibitor of drug metabolism… Expand
Studies of the different metabolic pathways of antipyrine in man
TLDR
It is concluded that the pharmacokinetic parameters of antipyrine can be satisfactorily established on the basis of salivary data, although the volume of distribution and clearance values are then slightly too high. Expand
Metronidazole and antipyrine metabolism in the rat: clearance determination from one saliva sample.
TLDR
A mixture of metronidazole and antipyrine and non-invasive sampling are recommendable for the study of the differential metabolism of foreign compounds in rats in vivo. Expand
Salivary antipyrine kinetics in hepatic and renal disease and in patients on anticonvulsant therapy.
TLDR
The results suggest that differences in the activity of hepatic microsomal enzymes are reflected by changes in salivary antipyrine elimination kinetics, and chronic renal failure appeared to have no effect on the function of these enzymes. Expand
Studies on the different metabolic pathways of antipyrine in man. I. Oral administration of 250, 500 and 1000 mg to healthy volunteers.
TLDR
From 12 h of drug intake onwards, the urinary excretion rate curves of antipyrine and all its metabolites declined mono-exponentially with about the same half-life as the parent compound in saliva. Expand
Sex difference in antipyrine 3-hydroxylation. An in vivo-in vitro correlation of antipyrine metabolism in two rat strains.
TLDR
It is found that higher production of 3-OH-antipyrine in vivo was paralleled by a higher intrinsic clearance in vitro while no sex difference in intrinsic clearance for the formation of the other metabolites was seen. Expand
Assessment of antipyrine kinetics from saliva or plasma: influence of age.
TLDR
The findings in the study indicate that the relationship between saliva and plasma kinetics in young subjects becomes less reproducible with age. Expand
Antipyrine: Radioimmunoassay in plasma and saliva following administration of a high dose and a low dose
TLDR
The radioimmunoassay can detect antipyrine levels as low as 10 ng/ml of plasma or saliva, using a 0.1‐ml sample, which contrasts with the sensitivity of a commonly used spectrophotometric method that can measure about 4,000 ng/ML using a 2‐ml plasma sample. Expand
Interaction between antipyrine and aminopyrine
TLDR
Antipyrine elimination was prolonged to the same extent when aminopyrine was given 5 hr before antipyrine as when the drugs were given simultaneously, and the marked inhibitory effects observed 5 hr after aminobyrine administration may be due to its major metabolite, 4‐aminoantipyrines. Expand
Simplified Determination of Antipyrine Clearance by Liquid Chromatography of a Microsample of Saliva or Plasma
TLDR
A simplified and rapid liquid chromatographic determination of antipyrine clearance (CLAP) calculated from peak height ratios of drug/internal standard is described, finding that the dose has no significant impact on this parameter. Expand
A non-invasive method for the study of hepatic drug metabolism in rodents: antineoplastic drug effects on antipyrine metabolism in mice.
A rapid, sensitive and simple high pressure liquid chromatography (HPLC) method is described for the direct analysis of antipyrine in saliva. The detection limit was found to be 1.0 ng/ml of sample,Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
The fate of antipyrine in man.
  • B. Brodie, J. Axelrod
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1950
TLDR
The transformation of antipyrine is slow, so that plasma levels after a single therapeutic dose decline only 1 to 12 per cent an hour, resulting in sustained plasma levels for fifteen hours or more, considerably longer than with acetanilide, phenacetin or N-acetyl p-aminophenol. Expand
The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.
TLDR
After discontinuance of dosage, the rate of biotransformation in man is slow, averaging about 20 per cent per day, but varies considerably in different subjects, and different species vary markedly in the rates at which they metabolize phenylbutazone. Expand
Salivary excretion of paracetamol in man
TLDR
The tacit assumption that drugs administered to man are excreted in the saliva has only been substantiated in a few cases, but the use of salivary excretion in the biochemical monitoring of industrial workers in hazardous environments has been proposed by Joselow, Ruiz & Goldwater (1969). Expand
Impairment of drug metabolism in man by allopurinol and nortriptyline.
TLDR
Results in rats support the interpretation that in man prolongation of antipyrine and bishydroxycoumarin half-lives after allopurinol or nortriptyline pretreatment is produced by reduced rates of drug biotransformation in liver microsomes. Expand
Correlation of the plasma elimination of antipyrine and the appearance of 4-hydroxy antipyrine in the urine of man.
TLDR
A new gas chromatographic method for the determination of antipyrine and 4-hydroxy antipyrines in biological fluids is described, and a significant correlation is found between the plasma elimination half-life of antip Kyrine and the rate of appearance of 4-Hydroxy antipyrsine conjugate in the urine. Expand
Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man.
TLDR
The results suggest that some inducing agents may be used to minimize individual variations in drug metabolism where such variations create therapeutic problems by exposing patients who slowly metabolize certain drugs to toxicity and other patients who rapidly metabolize some drugs to undertreatment. Expand
Plasma antipyrine half-life and hepatic microsomal antipyrine hydroxylase activity in rabbits.
TLDR
The half-lives of antipyrine did not change significantly after short-term or after long-term exposure to carbon monoxide gas, and Cytochrome P-450 content and anti pyrine hydroxylase activity in hepatic microsomal fraction of all animals was determined. Expand
Relationship between plasma antipyrine half-lives and hepatic microsomal drug metabolism in dogs.
TLDR
It is suggested that under certain conditions plasma antipyrine half-lives may be useful indices of rates of hepatic metabolism of several compounds chemically unrelated to antipyrines. Expand
MECHANISM OF HEPATIC DRUG OXIDATION AND ITS RELATIONSHIP TO INDIVIDUAL DIFFERENCES IN RATES OF OXIDATION IN MAN *
TLDR
Results indicate that the duration of action of hexobarbital depends on the rate at which it is oxidized by liver enzymes, and the contribution of differing rates of metabolism to individual differences in response to drugs can be eliminated if the subject's ability to oxidize drugs could be easily assessed. Expand
Implications of enzyme induction in drug toxicity studies.
TLDR
Data are presented which indicate that the plasma half-life of antipyrine, before and after drug treatment, may be a useful way of determining enhanced drug metabolism in the animal. Expand
...
1
2
3
4
...