Elimination of antibiotic-resistant plasmids by quinolone antibiotics.

  title={Elimination of antibiotic-resistant plasmids by quinolone antibiotics.},
  author={K P Fu and Marie E. Grace and Chiao Long Hsiao and Paul P. Hung},
  volume={34 5},
Of 7 plasmids we tested, the plasmid pORF2 was eliminated in vitro with the most efficiency by treatment with subinhibitory concentrations of novobiocin, coumermycin and 10 quinolones. It showed a cure rate of 43% by enoxacin; 12% by novobiocin, pefloxacin, ciprofloxacin and CI-934; 7% by coumermycin and ofloxacin; 9% by amifloxacin; and 4% by AM-833. On… CONTINUE READING