Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.

@article{Sagai2005EliminationOA,
  title={Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.},
  author={Tomoko Sagai and Masaki Hosoya and Youichi Mizushina and Masaru Tamura and Toshihiko Shiroishi},
  journal={Development},
  year={2005},
  volume={132 4},
  pages={797-803}
}
Mutations in a conserved non-coding region in intron 5 of the Lmbr1 locus, which is 1 Mb away from the sonic hedgehog (Shh) coding sequence, are responsible for mouse and human preaxial polydactyly with mirror-image digit duplications. In the mouse mutants, ectopic Shh expression is observed in the anterior mesenchyme of limb buds. Furthermore, a transgenic reporter gene flanked with this conserved non-coding region shows normal polarized expression in mouse limb buds. This conserved sequence… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 143 extracted citations

Mapping the Shh regulatory landscape

View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…