Elimination of Water from the Human Body

@article{Hevesy1934EliminationOW,
  title={Elimination of Water from the Human Body},
  author={George von Hevesy and E. Hofer},
  journal={Nature},
  year={1934},
  volume={134},
  pages={879-879}
}
SHORTLY after the first application of radioactive isotopes as indicators, the late H. J. G. Moseley and one of the present writers discussed the prospect opened by the introduction of this method, when indulging in a cup of tea at the Manchester Physics Laboratory. The latter then expressed the wish that an indicator might be found which would allow one to determine the fate of the individual water molecules contained in the cup of tea consumed. Even a man of the vision and outlook of the late… 
THE MEASUREMENT OF TOTAL BODYWATER IN THE HUMAN SUBJECT BY DEUTERIUM OXIDE DILUTION WITH A CONSIDERATION OF THE DYNAMICS OF DEUTERIUMDISTRIBUTION
The interpretation of fluctuations in body weight and changes in the state of hydration requires a knowledge of the total amount of water in the organism. This investigation has been directed towards
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  • Medicine
    Archives of disease in childhood
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The use of tritium in newborn children and the sources of error in the present method are described.
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The increasing availability and lowered cost of both stable and radioactive isotopes has made possible study of the total amount of liquid and solid water in the human subject.
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In order to obtain a high order of accuracy, the mass spectrometer is used in the measurement of deuterium concentration in body fluids in order to improve the accuracy of the measurements.
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The dilution technique in the measurement of body water in living animals was first suggested by observations on the rate of turnover of water in the body with deuterium as a reference substance and subsequently other reference materials such as tritium were proposed.
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A new deuterium nuclear magnetic resonance (2H NMR) method is described for determining total body water in humans that is fast, accurate, needs only a small dose of 2H2O, can be done using any body fluid, and, most importantly, does not require any sample preparation.
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