Elimination of LC-MS/MS matrix effect due to phospholipids using specific solid-phase extraction elution conditions.


BACKGROUND The objective is to find elution conditions using different solid-phase extraction chemistries to reduce the amount of phospholipids in plasma extract, which is associated with matrix effect in LC-MS. RESULTS Phospholipids' recovery was reduced by decreasing the eluents' methanol content applied to silica-based and polymer-based reversed-phase… (More)
DOI: 10.4155/bio.10.65