Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4.

@article{Reddy2000EliminationOF,
  title={Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4.},
  author={M. Pavan Reddy and Cheryl Ann S. Kinney and Margery A. Chaikin and Angela R. Payne and Jacqueline Fishman-Lobell and Ping Tsui and Paola Dal Monte and Michael L. Doyle and Michael R Brigham-Burke and Darrell Anderson and M. E. Reff and Roland Newman and Nabil Hanna and Raymond W. Sweet and Alemseged Truneh},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={1925-33}
}
Several CD4 mAbs have entered the clinic for the treatment of autoimmune diseases or transplant rejection. Most of these mAbs caused CD4 cell depletion, and some were murine mAbs which were further hampered by human anti-mouse Ab responses. To obviate these concerns, a primatized CD4 mAb, clenoliximab, was generated by fusing the V domains of a cynomolgus macaque mAb to human constant regions. The heavy chain constant region is a modified IgG4 containing two single residue substitutions… CONTINUE READING

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