Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep.

@article{Golenbock1988EliminationAT,
  title={Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep.},
  author={Douglas T Golenbock and Sara Ebert and James A. Will and Richard Anthony Proctor},
  journal={Antimicrobial agents and chemotherapy},
  year={1988},
  volume={32 1},
  pages={
          37-41
        }
}
Lipid X (2,3-diacylglucosamine 1-phosphate) is a novel monosaccharide precursor of lipid A (the active moiety of gram-negative endotoxin) and has been found to be protective against endotoxin administered to mice and sheep and against life-threatening gram-negative infections in mice. Because of the need to design optimal dosing regimens in experimental models of ovine and murine septicemia, the pharmacokinetic profile of lipid X was investigated in sheep and in two strains of mice by using 32P… CONTINUE READING
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