Eliminating membrane depolarization caused by the Alzheimer peptide Abeta(1-42, aggr.).

  title={Eliminating membrane depolarization caused by the Alzheimer peptide Abeta(1-42, aggr.).},
  author={B. Blanchard and B. Stockwell and V. Ingram},
  journal={Biochemical and biophysical research communications},
  volume={293 4},
  • B. Blanchard, B. Stockwell, V. Ingram
  • Published 2002
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • A high-throughput screen found compounds that eliminate the dramatic membrane depolarization caused by the aggregated Alzheimer Abeta1-42 peptide, which activates mGluR1 receptors. The library was composed of known biologically active compounds; the cell-based assay measured the changes of membrane potential with a slow-acting voltage-sensitive dye. We found 10 potentially useful compounds, some of which reduce the Abeta-induced membrane depolarization up to 96%. Interestingly, the active… CONTINUE READING
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