Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion.

@article{Lieu2003EliminatingAI,
  title={Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion.},
  author={Hsiao Dee Lieu and Shannon K Withycombe and Quinn M. Walker and James X. Rong and Rosemary L. Walzem and Jinny S. Wong and Robert Lewis Hamilton and Edward A Fisher and Stephen G. Young},
  journal={Circulation},
  year={2003},
  volume={107 9},
  pages={
          1315-21
        }
}
BACKGROUND LDL receptor-deficient "apolipoprotein (apo)-B100-only" mice (Ldlr-/-Apob100/100 have elevated LDL cholesterol levels on a chow diet and develop severe aortic atherosclerosis. We hypothesized that both the hypercholesterolemia and the susceptibility to atherosclerosis could be eliminated by switching off hepatic lipoprotein production. METHODS AND RESULTS We bred Ldlr-/-Apob100/100 mice that were homozygous for a conditional allele for Mttp (the gene for microsomal triglyceride… CONTINUE READING

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