Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs.

@article{Tseng2006ElicitedAI,
  title={Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs.},
  author={Yau-Lin Tseng and Kathleen M Moran and Frank J M F Dor and Todd M Sanderson and Wei Li and Courtney J Lancos and Henk-Jan Schuurman and David H Sachs and David K C Cooper},
  journal={Transplantation},
  year={2006},
  volume={81 7},
  pages={1058-62}
}
BACKGROUND This study investigates anti-nonGal antibodies (Abs) in baboons after alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pig heart transplantation (Tx). METHODS Four baboons underwent pig heart Tx under chronic immunosuppression, which was discontinued after graftectomy. During follow-up, one baboon also received a pig splenocyte infusion. Hearts and splenocytes were from GalT-KO pigs (n = 3) or pigs with low Gal expression (Gal-low, n = 2), all of swine leukocyte antigen (SLA… CONTINUE READING

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