Elicitation of specific, Th1-biased immune response precludes skeletal muscle damage in cruzipain-vaccinated mice.

@article{Frank2008ElicitationOS,
  title={Elicitation of specific, Th1-biased immune response precludes skeletal muscle damage in cruzipain-vaccinated mice.},
  author={Fernanda Mar{\'i}a Frank and Silvia In{\'e}s Cazorla and Mar{\'i}a Jos{\'e} Sartori and Ricardo Santiago Corral},
  journal={Experimental and molecular pathology},
  year={2008},
  volume={84 1},
  pages={64-70}
}
Cruzipain (Cz), the major cystein proteinase of Trypanosoma cruzi, is able to induce protective immunity against parasite challenge. However, some concern has arisen regarding its potential to elicit pathogenic autoimmune reactivity. To determine whether the adverse myopathic effects of Cz-based immunization could be prevented, we evaluated the co-administration of Cz with different adjuvants. Mice were immunized with Cz adjuvantized by alum (Cz+alum), oligodeoxynucleotides containing CpG… CONTINUE READING