Elicitation of secondary metabolism in actinomycetes.

@article{Abdelmohsen2015ElicitationOS,
  title={Elicitation of secondary metabolism in actinomycetes.},
  author={Usama Ramadan Abdelmohsen and Tanja Grkovic and Srikkanth Balasubramanian and Mohamed Salah Kamel and Ronald J. Quinn and Ute Hentschel},
  journal={Biotechnology advances},
  year={2015},
  volume={33 6 Pt 1},
  pages={
          798-811
        }
}
Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions. This review focuses on the effects of biological (co-cultivation), chemical, as well as molecular elicitation on secondary metabolism in actinomycetes. Our review covers the literature until June 2014 and exemplifies the diversity of natural… CONTINUE READING
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