Elicitation of Taxus sp. cell cultures for production of taxol

@article{Ciddi2004ElicitationOT,
  title={Elicitation of Taxus sp. cell cultures for production of taxol},
  author={Veeresham Ciddi and Venkatesh Srinivasan and Michael L. Shuler},
  journal={Biotechnology Letters},
  year={2004},
  volume={17},
  pages={1343-1346}
}
SummaryThe addition of cell extracts and cultures filtrate of Pencillium minioluteum, Botrytis cinerea, Verticillium dahliae, and Gilocladium deliqucescens on the tenth day after transferring Taxus sp. (RO1-M28) cell suspensions into an induction medium, further improved the production of TaxolTaxol is a registered trademark of Bristol Myers Squibb for paclitaxel. and total taxanes. Arachidonic acid (1mg/L) addition at the time of inoculation increased Taxol production by 150%. Oxidative stress… 
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67 Citations
Highly Influential Citations
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Background Citations
18
Methods Citations
3

67 Citations

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Fungal elicitor-induced cell apoptosis in suspension cultures of Taxus chinensis var. mairei for taxol production
Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures.
Induction studies of methyl jasmonate and salicylic acid on taxane production in suspension cultures of Taxus chinensis var. mairei
Plant cell culture for production of paclitaxel and other taxanes.
  • J. Zhong
  • Biology, Engineering
    Journal of bioscience and bioengineering
  • 2002
The role of lipoxygenase in elicitor-induced taxol production in Taxus chinensis cell cultures
Enhanced paclitaxel production induced by the combination of elicitors in cell suspension cultures of Taxus chinensis
Taxus chinensis suspension cells were cultured in the modified Gamborg's B5 medium. Addition of 50 mg chitosan l−1, 60 μM methyl jasmonate and 30 μM Ag+ resulted in the greatest paclitaxel…
Methyl jasmonate stimulates jaceosidin and hispidulin production in cell cultures of Saussurea medusa
TLDR
It is observed that the activities of phenylalanine ammonia lyase were transiently increased after treatment with MJ, which suggests that this elicitor modifies jaceosidin and hispidulin production by regulating the phenylpropanoid pathway.
Involvement of NO in fungal elicitor-induced activation of PAL and stimulation of taxol synthesis inTaxus chinensis suspension cells
TLDR
It is indicated that NO, produced via NOS in taxus chinensis cells treated with fungal elicitor, might act as an essential signaling molecule for triggering the activation of PAL and synthesis of taxol.
Oxidative Stress and Taxol Production Induced by Fungal Elicitor in Cell Suspension Cultures of Taxus Chinensis
TLDR
It is concluded that oxidative stress had the deleterious effect onTaxus chinensis cell suspension cultures with fungal elicitor and ascorbic acid changed the oxidative stress and taxol production.
Production of Taxol and its Analogues from Cell Cultures of Taxus wallichiana
TLDR
Preursors and growth retardants significantly improved the production of taxol, DAB and BA in cultures grown in production medium and on HPLC analysis using photodiode array detector.
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References

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TLDR
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